THE GABA-A RECEPTOR
A MAJOR THERAPEUTIC CHANNEL
Neurosteroids are some of the body’s most powerful, high-impact compounds. They exert huge influence over our lives, modulating our emotions, reward and pleasure centers, and emotional, cognitive and memory functions. But which compounds modulate them? A new generation of highly specific therapeutic compounds can now potentially “modulate the modulators” and “control the controllers”. They too operate within the GABA-A receptors—the brain’s major inhibitory signaling system, and a fast-emerging therapeutic channel.
NEUROSTEROIDS AND GABA-A RECEPTORS
Allopregnanolone, THDOC, Androstanediol and Pregnanolone—few have heard of them, yet they are powerful neurosteroids with a major impact on all of us.
Synthesized in both the brain and endocrine glands, these potent neurochemicals enter our bloodstream and affect our brain functions, producing a wide range of effects ranging from stress- and anxiety- reduction to analgesia and sedation but can also, in diseased individuals, cause the opposite effects. The neurosteroids are highly active within, and primarily target, the brain’s GABA-A receptors.