Sepranolone’s inhibitory effect is highly specific to ALLO—so it does not interfere with GABA itself or other GABA agonists’ effect on the receptor (e.g. benzodiazepines) (1).
Early research into Sepranolone on mouse models of Tourette symptoms, for example, highlights its potential to reduce tics with the same efficacy as today’s most efficacious current therap (Haldol), but none of its serious side effects. (Haldol’s side effects range from blurred vision, nausea and diarrhoea to severe involuntary movement disorder, irregular heartbeat and even renal failure.)