THE PHARMACOKINETIC EFFECTS OF SEPRANOLONE
The physiological and neurological effects of ALLO are clear and well-known, with its potential as a pharmaceutical treatment long discussed. In a 2006 study – Pharmacokinetic and behavioral effects of Allopregnanolone in healthy women – ALLO-induced physical signals were demonstrated in women given three different doses of ALLO. ALLO-induced sedation and reduced Saccadic Eye Velocity (SEV), a recognized marker on the activation of the GABA-A system, were observed (1).
In vivo studies also show the effect of Sepranolone in reducing the physical and behavioral effects of ALLO. In preclinical rat models Sepranolone significantly ameliorated ALLO-induced anaesthesia (2) and ALLO-induced anxiety and oestrus-cycle dependent aggressivity (3). University of Utah research showed Sepranolone reduced tics in a D1CT-7 mouse model of Tourette’s syndrome without inducing any motor side effects (4).