In vivo studies also show the effect of Sepranolone in reducing the physical and behavioral effects of ALLO. In preclinical rat models Sepranolone significantly ameliorated ALLO-induced anaesthesia (2) and ALLO-induced anxiety and oestrus-cycle dependent aggressivity (3). University of Utah research showed Sepranolone reduced tics in a D1CT-7 mouse model of Tourette’s syndrome without inducing any motor side effects (4).