Yet developing a safe treatment with few side effects remains a challenge. Tourette is a complex condition. As with many other neurosteroid and hormone conditions, it is severely aggravated by stress. Complex co-morbidities with other stress disorders are common: 86% of patients with Tourette have at least one additional behavioral or developmental disorder (Univ. California, San Francisco) – ranging from ADHD, OCD/B, inattention, hyperactivity, impulsivity and childhood conduct disorder – all of which could also be heavily impacted by Allopregnanolone, the same potent neurosteroid that plays a key role in PMDD.