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How does Sepranolone work?


Sepranolone normalizes the spontaneous GABA-A receptor activity induced by Allopregnanolone. It does this by inhibiting the Positive Allosteric Modulation (PAM) effect of ALLO within the GABA-A receptor.

The finely targeted specificity of Sepranolone means that it is confined to a very specific part of the GABA-A receptor, with minimal effect on any other CNS mechanism—meaning little or no side effects as a treatment:

  • Fine-tuned receptor activity without overstimulation
  • High selectivity
  • Minimal off-target effect